Prognosis and assessment tools
To facilitate diagnosis, a number of standardized assessment tools and scales to track patients transitioning between unconsciousness and consciousness have been developed.1 The revision of the Coma Recovery Scale includes all the behavioral criteria necessary to diagnose those individuals in a minimally conscious state (MCS), and those emerging from MCS, according to the clinical criteria established by the Aspen Workgroup. Some studies that involved these neurologic situations focused on describing predictors of outcome. Age, chronicity, etiology are the most common predictors of outcome analyzed in previous investigations. Since the categorization of MCS in most of the studies were made based on a retrospective analysis of clinical data, with a significant effort to match any clinical sign observed along the evolution of the disease with actual standardized clinical criteria. Data derived from initial retrospective analysis suggested that, in contrast to patients in an unresponsive wakefulness syndrome (UWS), those in an MCS may have better short- and long-term outcomes.
We conducted a prospective study describing the clinical characteristics and short-term pattern of evolution
of a sample of individuals within one year after a brain injury that led to a UWS or an MCS according to
their scores on the Spanish version of the Coma Recovery Scale–Revised, aiming to provide practitioners with
a useful tool for prospective evaluation of those neurologic aspects that are of clinical and prognostic
relevance in this population.2
Our results showed that emergence from an MCS was mostly associated with improvement in both the communication and motor function scales. Lesser chronicity and the presence of more than visual behavioral responses at admission were both significant predictors of emergence from an MCS. The CRS-R proved to be appropriate for establishing an immediate prognosis in this population.
In addition, in another study we found a significant high correlation between our version of the CRS-R and
the Loewenstein Communication Scale and a moderate correlation with the Disability Rating Scale, while no
significant correlation with the Glasgow Coma Scale.3
These results the existing differences among tools for assessing disorders of consciousness.
- Noé E., Moliner B., O’Valle M., Balmaseda R., Colomer C., Navarro M.D., Ferri J. Del Estado vegetativo al de vigilia sin respuesta. Una revisión histórica. Revista de Neurología, 2012. 55(5): 306-13.
- Noé E., Olaya J., Navarro M.D., Noguera P., Colomer C., García-Panach J., Rivero S., Moliner B., Ferri J. Behavioral recovery in disorders of consciousness: a prospective study with the Spanish version of the Coma Recovery Scale-Revised. Archives of Physical Medicinie Rehabilitation, 2012 Mar;93(3):428-33.
- Ferri J., Noé E., Llorens R. The Spanish version of the coma recovery scale-revised: Events on a correct timeline. Brain Injury. 2015. 21:1-2.